In our next NSI Rising Star Seminar, we will be hosting Mohamed Abdel Hakeem (PhD, Assistant Professor at Emory University) with a talk on “Dissecting T cell differentiation”. Look forward to seeing you there!
Meeting details:
Speaker: Mohamed Abdel Hakeem
Title: Dissecting T cell differentiation
Time and date: Wednesday, September 24 at 10:00
Meeting link: https://uio.zoom.us/j/66789985517?pwd=tk0ISk0WVqj6asOCpM2E35a8N5UJqb.1
Talk abstract:
Hakeem Lab at Emory Vaccine Center continues to focus on dissecting the molecular programs of T cells in chronic settings, with the overarching goal of developing next-generation immunotherapies and enhancing vaccine responses. For these aims, Hakeem Lab utilized novel approaches, for example, performing the first in vivo proteomic and phosphoproteomic profiling of T cell exhaustion. Also, exploring the impact of preexisting chronic disease on memory immune responses to subsequent acute stimuli.
More information about Mohamed Abdel Hakeem:
Mohamed Abdel Hakeem is an Assistant Professor at Emory, following a Postdoc training at the University of Pennsylvania, after an M.Sc. and a PhD at Université de Montréal. Throughout his research journey, he studied differentiation of immune cells, with a focus on T cells, especially in chronic settings. He co-authored more than 30 manuscripts representing studies in animal models and using human samples in various scientific journals, including Nature Immunology, Science Immunology, Journal of Science Immunology, PLOS Pathogens, and PNAS, where he also serves as a reviewer.
Google scholar: https://scholar.google.com/citations?user=z_ndQb8AAAAJ&hl=en
Key papers:
1. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation.
2. Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance